HEFT Repository

Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?

Pallayova, Maria and Rayner, Hugh C and Taheri, Shahrad and Dasgupta, Indranil (2015) Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function? Journal of diabetes and its complications. ISSN 1873-460X. This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs

Full text not available from this repository.
Official URL: http://www.jdcjournal.com/article/S1056-8727(15)00...

Abstract

AIMS

We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period.

METHODS

We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60ml/min/1.73m(2) over 5years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians.

RESULTS

Despite similar baseline eGFR (P=0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P<0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P=0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P=0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P=0.064).

CONCLUSIONS

Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs
Subjects: WJ Urogenital system. Urology
WK Endocrine system. Endocrinology
Divisions: Emergency Services > Renal
Related URLs:
Depositing User: Preeti Puligari
Date Deposited: 29 Jun 2015 13:51
Last Modified: 29 Jun 2015 14:39
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/993

Actions (login required)

View Item View Item