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Is cardiac resynchronisation therapy proarrhythmic?

Leyva, Francisco and Foley, Paul Wx (2008) Is cardiac resynchronisation therapy proarrhythmic? Indian pacing and electrophysiology journal, 8 (4). pp. 268-80. ISSN 0972-6292.

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Official URL: http://ipej.org/ojs237/index.php/ipej/index

Abstract

It is well established that cardiac resynchronisation therapy (CRT) using biventricular pacing prolongs survival by its effects on pump failure. The rate of sudden cardiac death in patients undergoing CRT, however, remains high. Animal and human studies have shown that reversal of normal sequence of myocardial activation during epicardial pacing, as applied during CRT, increases the transmural dispersion of repolarisation (TDR), a substrate for ventricular arrhythmias. Cohort studies in humans suggest that CRT has a differential effect on the arrhythmogenic substrate, antiarrhythmic in some and proarrhythmic in others. This review the focuses on the possibility that CRT may, under certain circumstances, promote arrhythmogenesis.

Item Type: Article
Subjects: WG Cardiovascular system. Cardiology
Divisions: Emergency Services > Cardiology
Depositing User: Users 6 not found.
Date Deposited: 17 Nov 2013 11:27
Last Modified: 17 Nov 2013 11:27
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/99

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