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Icatibant in the treatment of Angiotensin-converting enzyme inhibitor-induced angioedema.

Crooks, Neil H and Patel, Jaimin and Diwakar, Lavanya and Smith, Fang Gao (2014) Icatibant in the treatment of Angiotensin-converting enzyme inhibitor-induced angioedema. Case reports in critical care, 2014. p. 864815. ISSN 2090-6420.

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Official URL: http://www.hindawi.com/journals/cricc/2014/864815/

Abstract

We describe the case of a 75-year-old woman who presented with massive tongue and lip swelling secondary to angiotensin-converting enzyme inhibitor-induced angioedema. An awake fibre-optic intubation was performed because of impending airway obstruction. As there was no improvement in symptoms after 72 hours, the selective bradykinin B2 receptor antagonist icatibant (Firazyr) was administered and the patient's trachea was successfully extubated 36 hours later. To our knowledge this is the first documented case of icatibant being used for the treatment of angiotensin-converting enzyme inhibitor-induced angioedema in the United Kingdom and represents a novel therapeutic option in its management.

Item Type: Article
Subjects: WG Cardiovascular system. Cardiology
Divisions: Emergency Services > Cardiology
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 20 May 2015 14:50
Last Modified: 20 May 2015 14:50
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/924

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