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The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis.

Stradling, Clare and Chen, Yen-Fu and Russell, Tracy and Connock, Martin and Thomas, G Neil and Taheri, Shahrad (2012) The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. PloS one, 7 (6). e38121. ISSN 1932-6203.

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Official URL: http://www.plosone.org/article/info%3Adoi%2F10.137...

Abstract

BACKGROUND: Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established. METHODS: We conducted a systematic search of electronic databases supplemented with manual searches and conference abstracts, without language restriction. All randomised controlled trials (RCTs) with blood lipid outcomes, involving dietary intervention or supplementation for the treatment or prevention of adult HIV dyslipidaemia, versus no or other intervention were included. Two authors using predefined data fields, including study quality indicators, extracted data independently. RESULTS: Eighteen studies (n = 873) met our inclusion criteria. Seven RCTs for omega-3 supplementation (n = 372), and four RCTs for dietary intervention (n = 201) were meta-analysed using random-effects models. Mild statistical heterogeneity was observed. Dietary intervention reduced triglyceride levels by -0·46 mmol/l (95%CI: -0·85 to -0·07 mmol/l) compared to control. Omega-3 supplementation reduced triglyceride levels by -1.12 mmol/l, (95%CI: -1·57 to -0·67 mmol/l) and total cholesterol, -0·36 mmol/l (95%CI: -0·67 to -0·05 mmol/l) compared to placebo/control. CONCLUSIONS: Both omega-3 supplementation and dietary intervention reduced triglyceride level, with the latter possibly to a smaller extent. While dietary interventions are beneficial, more stringent dietary approaches may be necessary to fully address lipid disturbances in HIV patients.

Item Type: Article
Subjects: WC Communicabable diseases
Divisions: Ambulatory Care > Diabetes
Clinical Support > Infectious Diseases
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Depositing User: Preeti Puligari
Date Deposited: 26 Apr 2013 15:22
Last Modified: 26 Apr 2013 15:22
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/92

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