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Multidrug-resistant Gram-negative bacteria: a product of globalization.

Hawkey, P M (2015) Multidrug-resistant Gram-negative bacteria: a product of globalization. The Journal of hospital infection, 89 (4). pp. 241-7. ISSN 1532-2939. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login ID's.

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Official URL: http://www.journalofhospitalinfection.com/article/...

Abstract

Global trade and mobility of people has increased rapidly over the last 20 years. This has had profound consequences for the evolution and the movement of antibiotic resistance genes. There is increasing exposure of populations all around the world to resistant bacteria arising in the emerging economies. Arguably the most important development of the last two decades in the field of antibiotic resistance is the emergence and spread of extended-spectrum β-lactamases (ESBLs) of the CTX-M group. A consequence of the very high rates of ESBL production among Enterobacteriaceae in Asian countries is that there is a substantial use of carbapenem antibiotics, resulting in the emergence of plasmid-mediated resistance to carbapenems. This article reviews the emergence and spread of multidrug-resistant Gram-negative bacteria, focuses on three particular carbapenemases ‒ imipenem carbapenemases, Klebsiella pneumoniae carbapenemase, and New Delhi metallo-β-lactamase ‒ and highlights the importance of control of antibiotic use.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login ID's.
Subjects: QW Microbiology. Immunology
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Adele Creak
Date Deposited: 30 May 2015 08:18
Last Modified: 30 May 2015 08:18
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/893

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