Disease recurrence following cetuximab completion and declining a gastrectomy: what next to manage Ménétriers disease?

Patel, Mitesh and Mottershead, Marcus (2014) Disease recurrence following cetuximab completion and declining a gastrectomy: what next to manage Ménétriers disease? BMJ case reports, 2014. ISSN 1757-790X. This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs

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Abstract

Ménétriers disease is a rare mucosal hyperproliferative disorder of the stomach, however, the evidence for long-term care remains limited, especially if a gastrectomy is declined. We present a case of 25-year-old Caucasian woman with a history of end-stage renal failure (ESRF) who experienced worsening symptoms of abdominal pain, haematemesis and abdominal swelling, with her serum albumin dropping to 20 g/L and haemoglobin to 4.9 g/dL. Endoscopy showed markedly hyperplastic gastric folds consistent with Ménétriers disease, confirmed histologically by gland dilation and gastric pit expansion. Intravenous cetuximab was prescribed for 12 months, with clinical, biochemical and endoscopic improvement. However, 5 weeks post cetuximab completion, there was relapse to 50% gastric coverage with Ménétriers. A discussion around gastrectomy was rejected by the patient. This is the first report of relapsing Ménétriers disease in a female patient with ESRF; we suggest that long-term cetuximab should be considered if a gastrectomy is declined.

Item Type:	Article
Additional Information:	This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs
Subjects:	WI Digestive system. Gastroenterology
Divisions:	Planned IP Care > Gastroentrology
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/?term...
Depositing User:	Mrs Yolande Brookes
Date Deposited:	16 Apr 2015 12:27
Last Modified:	16 Apr 2015 12:27
URI:	http://www.repository.heartofengland.nhs.uk/id/eprint/848

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