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Surveillance of antibiotic susceptibility of urinary tract pathogens for a population of 5.6 million over 4 years.

Ironmonger, Dean and Edeghere, Obaghe and Bains, Amardeep and Loy, Richard and Woodford, Neil and Hawkey, Peter M (2015) Surveillance of antibiotic susceptibility of urinary tract pathogens for a population of 5.6 million over 4 years. The Journal of antimicrobial chemotherapy, 70 (6). pp. 1744-1750. ISSN 1460-2091. (Unpublished)

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Official URL: http://jac.oxfordjournals.org/content/early/2015/0...

Abstract

OBJECTIVES

To retrospectively analyse routine susceptibility testing data to describe antimicrobial non-susceptibility trends in isolates of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa from urine samples in a population of 5.6 million people over a 4 year period.

METHODS

De-duplicated laboratory data submitted to the AmSurv surveillance system from the West Midlands region of England and results of submissions to the Antimicrobial Resistance and Healthcare Associated Infections Reference Unit were extracted for the period 2010-13. Descriptive analysis of the non-susceptibility of selected Gram-negative organisms to key antibiotics, as recommended for monitoring in the UK Five Year Antimicrobial Resistance Strategy, was undertaken.

RESULTS

During the study period, there were 431 461 reports for E. coli, 23 786 for K. pneumoniae and 6985 for P. aeruginosa from urine specimens. These represented 61%, 3% and 1%, respectively, of all organisms isolated from urine specimens. There was a linear increase in non-susceptibility to third-generation cephalosporins for E. coli and K. pneumoniae, and to ciprofloxacin for E. coli, in specimens from both hospital and community settings (P < 0.001). The proportions of E. coli and K. pneumoniae reported non-susceptible to meropenem and/or imipenem remained low during the study period, with no evidence of linear trend (P ≥ 0.05).

CONCLUSIONS

Automated antimicrobial resistance surveillance enabled, for the first time in England, the systematic monitoring of resistance in bacteria responsible for urinary tract infections in a defined population, and thereby provided a representative indication of the burden of resistance in Gram-negative bacteria in hospital and community settings.

Item Type: Article
Subjects: QW Microbiology. Immunology
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Miss Adele Stanton
Date Deposited: 30 May 2015 07:11
Last Modified: 30 May 2015 07:11
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/837

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