Xu, Li and Shabir, Sahida and Bodah, Thomas and McMurray, Claire and Hardy, Katie and Hawkey, Peter M and Nye, Kathryn (2011) Regional survey of CTX-M-type extended-spectrum β-lactamases among Enterobacteriaceae reveals marked heterogeneity in the distribution of the ST131 clone. The Journal of Antimicrobial Chemotherapy, 66 (3). pp. 505-11. ISSN 1460-2091.Full text not available from this repository.
The CTX-M-15-producing RE1 clone (strain A) is the predominant clone in the West Midlands. This clone has spread throughout the region since its emergence in an outbreak 3 years earlier. Most, but not all, RE1 isolates belong to the O25b-ST131 lineage, providing further evidence that this lineage plays a pivotal role in the clonal dispersal of CTX-M-15-producing Enterobacteriaceae. Strain A was found to be considerably more heterogeneous than when first described and has acquired greater resistance to gentamicin. Approximately one-third of CTX-M producers represented a wide variety of unrelated strains. The study shows the rapid spread and diversification of CTX-M-producing Enterobacteriaceae over a 3 year period.
|Subjects:||QY Clinical pathology|
|Divisions:||Clinical Support > Pathology|
|Depositing User:||Mrs Caroline Tranter|
|Date Deposited:||15 May 2013 08:40|
|Last Modified:||15 May 2013 08:43|
Actions (login required)