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Regional survey of CTX-M-type extended-spectrum β-lactamases among Enterobacteriaceae reveals marked heterogeneity in the distribution of the ST131 clone.

Xu, Li and Shabir, Sahida and Bodah, Thomas and McMurray, Claire and Hardy, Katie and Hawkey, Peter M and Nye, Kathryn (2011) Regional survey of CTX-M-type extended-spectrum β-lactamases among Enterobacteriaceae reveals marked heterogeneity in the distribution of the ST131 clone. The Journal of Antimicrobial Chemotherapy, 66 (3). pp. 505-11. ISSN 1460-2091.

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Official URL: http://jac.oxfordjournals.org/content/66/3/505.ful...

Abstract

The CTX-M-15-producing RE1 clone (strain A) is the predominant clone in the West Midlands. This clone has spread throughout the region since its emergence in an outbreak 3 years earlier. Most, but not all, RE1 isolates belong to the O25b-ST131 lineage, providing further evidence that this lineage plays a pivotal role in the clonal dispersal of CTX-M-15-producing Enterobacteriaceae. Strain A was found to be considerably more heterogeneous than when first described and has acquired greater resistance to gentamicin. Approximately one-third of CTX-M producers represented a wide variety of unrelated strains. The study shows the rapid spread and diversification of CTX-M-producing Enterobacteriaceae over a 3 year period.

Item Type: Article
Subjects: QY Clinical pathology
Divisions: Clinical Support > Pathology
Depositing User: Mrs Caroline Tranter
Date Deposited: 15 May 2013 08:40
Last Modified: 15 May 2013 08:43
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/83

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