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BinaxNOW® - an immunochromatographic test for the diagnosis of human influenza viruses: comparison with viral culture and polymerase chain reaction.

Bhattacharya, S and Osman, H (2011) BinaxNOW® - an immunochromatographic test for the diagnosis of human influenza viruses: comparison with viral culture and polymerase chain reaction. Indian Journal of Medical Microbiology, 29 (1). pp. 19-21. ISSN 1998-3646.

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Official URL: http://www.ijmm.org/text.asp?2011/29/1/19/76518

Abstract

Purpose: A rapid test for influenza viruses (Binax NOW® ) was evaluated. Materials and Methods: In season-1, 35 respiratory samples were tested retrospectively; in season-2, 45 samples were tested prospectively [gold-standard: viral culture in season-1, culture+ reverse transcriptase-polymerase chain reaction (RT-PCR) in season-2]. Results: Sensitivity for Binax for influenza A was 59.3 and 0% in season-1 and -2, respectively. Sensitivity was low for influenza B (33.3% in season-1, 26.1% in season-2). Samples having low viral load were more likely to have a negative Binax test. Specificity of Binax was high (100 and 94.7% with influenza A and B, respectively). Conclusion: Sensitivity information provided in the kit insert does not always reflect post licensure performance in clinical settings.

Item Type: Article
Subjects: QY Clinical pathology
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Caroline Tranter
Date Deposited: 14 May 2013 08:47
Last Modified: 14 May 2013 08:47
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/74

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