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Recovery time, quality of life, and mortality in hemodialysis patients: the Dialysis Outcomes and Practice Patterns Study (DOPPS).

Rayner, Hugh C and Zepel, Lindsay and Fuller, Douglas S and Morgenstern, Hal and Karaboyas, Angelo and Culleton, Bruce F and Mapes, Donna L and Lopes, Antonio A and Gillespie, Brenda W and Hasegawa, Takeshi and Saran, Rajiv and Tentori, Francesca and Hecking, Manfred and Pisoni, Ronald L and Robinson, Bruce M (2014) Recovery time, quality of life, and mortality in hemodialysis patients: the Dialysis Outcomes and Practice Patterns Study (DOPPS). American journal of kidney diseases : the official journal of the National Kidney Foundation, 64 (1). pp. 86-94. ISSN 1523-6838. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login Ids

Full text not available from this repository.
Official URL: http://www.ajkd.org/article/S0272-6386(14)00031-6/...

Abstract

BACKGROUND

There is limited information about the clinical and prognostic significance of patient-reported recovery time.

STUDY DESIGN

Prospective cohort study.

SETTING & PARTICIPANTS

6,040 patients in the DOPPS (Dialysis Outcomes and Practice Patterns Study).

PREDICTOR

Answer to question "How long does it take you to recover from a dialysis session?" categorized as follows: fewer than 2, 2-6, 7-12, or longer than 12 hours.

OUTCOMES & MEASUREMENTS

Cross-sectional and longitudinal associations between recovery time and patient characteristics, hemodialysis treatment variables, health-related quality of life (HRQoL), and hospitalization and mortality.

RESULTS

32% reported recovery time shorter than 2 hours; 41%, 2-6 hours; 17%, 7-12 hours; and 10%, longer than 12 hours. Using proportional odds (ordinal) logistic regression, shorter recovery time was associated with male sex, full-time employment, and higher serum albumin level. Longer recovery time was associated with older age, dialysis vintage, body mass index, diabetes, and psychiatric disorder. Greater intradialytic weight loss, longer dialysis session length, and lower dialysate sodium concentration were associated with longer recovery time. In facilities that used uniform dialysate sodium concentrations for ≥90% of patients, the adjusted OR of longer recovery time, comparing dialysate sodium concentration<140 vs 140 mEq/L, was 1.72 (95% CI, 1.37-2.16). Recovery time was correlated positively with symptoms of kidney failure and kidney disease burden score and inversely with HRQoL mental and physical component summary scores. Using Cox regression, adjusting for potential confounders not influenced by recovery time, it was associated positively with first hospitalization and mortality (adjusted HRs for recovery time>12 vs 2-6 hours 1.22 [95% CI, 1.09-1.37] and 1.47 [95% CI, 1.19-1.83], respectively).

LIMITATIONS

Answers are subjective and not supported by physiologic measurements.

CONCLUSIONS

Recovery time can be used to identify patients with poorer HRQoL and higher risks of hospitalization and mortality. Interventions to reduce recovery time and possibly improve clinical outcomes, such as increasing dialysate sodium concentration, need to be tested in randomized trials.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login Ids
Subjects: WK Endocrine system. Endocrinology
Divisions: Emergency Services > Renal
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 05 Sep 2014 12:49
Last Modified: 05 Sep 2014 12:49
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/720

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