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CT Colonography to exclude colorectal cancer in symptomatic patients.

Badiani, Sarit and Hernandez, Silvia Tomas and Karandikar, Sharad S and Roy-Choudhury, Shuvro (2011) CT Colonography to exclude colorectal cancer in symptomatic patients. European radiology, 21 (10). pp. 2029-38. ISSN 1432-1084. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs

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Official URL: http://link.springer.com/article/10.1007%2Fs00330-...

Abstract

OBJECTIVES

CT Colonography (CTC) is being increasingly used for the radiological evaluation of colorectal symptoms. Aim of this study was to assess the role of CTC in excluding a colorectal cancer (CRC) in older symptomatic patients.

METHODS

1,359 CTC studies performed between March 2002 and December 2007 were analysed retrospectively. Gold standard was an endoscopic examination within 1 year and/or clinical, endoscopic and/or radiological follow-up until the time of data analysis. Patients not diagnosed as having a CRC on CTC were assumed as true-negatives if the gold standard was negative and did not feature on the regional cancer registry (at least 18 months post-CTC). Sensitivity, specificity, positive and negative predictive values were calculated for detection of colorectal cancer.

RESULTS

After exclusions, 1,177 CTC studies were included. These were undertaken in 463 men and 714 women. Median age of patients undergoing CTC was 71 (range, 27-96) years. 59 invasive CRC were detected. Median follow-up was 34.5 (range 18-84) months. Three small colorectal cancers were missed. Sensitivity and negative predictive value for CRC were 94.9% (95% CI:84.9%-98.7%) and 99.7% (95% CI:99.1%-99.9%) respectively.

CONCLUSIONS

CTC has a high sensitivity and negative predictive value in excluding a CRC in patients with colorectal symptoms.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Subjects: WI Digestive system. Gastroenterology
WN Medical imaging. Radiology
Divisions: Planned IP Care > Gastroentrology
Related URLs:
Depositing User: Mrs Caroline Tranter
Date Deposited: 02 Dec 2014 11:10
Last Modified: 02 Dec 2014 11:10
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/716

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