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Rheumatoid arthritis disease activity and vitamin D deficiency in an Asian resident population.

Quraishi, Mohammed K and Badsha, Humeira (2013) Rheumatoid arthritis disease activity and vitamin D deficiency in an Asian resident population. International journal of rheumatic diseases. ISSN 1756-185X.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/1756-18...

Abstract

AIM

We aimed to assess the prevalence of vitamin D deficiency and its association with rheumatoid arthritis (RA) disease activity in a UAE population.

METHODS

Forty-five consecutive subjects were prospectively recruited during the early summer with their clinical examination and Health Assessment Questionnaire (HAQ) being recorded at a clinic appointment, along with their blood sample being taken for the 25-hydroxyvitamin D (25(OH)D) total test.

RESULTS

Thirty-five (76%) patients claimed to be exposed to sunlight for < 30 min daily. The prevalence of vitamin D insufficiency (20-30 ng/mL) and deficiency (< 20 ng/mL) was 36% and 29%, respectively. RA patients who exposed their hands and feet (29 ng/mL) or more (34 ng/mL) to the sunlight had serum vitamin D levels higher than those who exposed their hands alone (18 ng/mL) or less (19 ng/mL) (P < 0.05). The variations in vitamin D levels due to skin color did not reach significance. No significant correlation was seen between serum vitamin D levels and Disease Activity Score (DAS28) or HAQ scores. A direct relationship was observed between HAQ scores and DAS28 scores (P < 0.05).

CONCLUSION

We highlight the importance of skin exposure to sunlight in a conservative dressing culture. No association was observed between vitamin D and disease activity. However, the high prevalence of vitamin D deficiency may negatively impact on bone health of these patients in the future.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD811 Rheumatology
Divisions: Emergency Services > Renal
Related URLs:
Depositing User: Mrs Suganthi Vijayaganesh
Date Deposited: 08 Dec 2014 14:26
Last Modified: 08 Dec 2014 14:26
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/688

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