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Food-dependent exercise-induced anaphylaxis: is wheat unique?

Wong, Gabriel K and Krishna, Mamidipudi T (2013) Food-dependent exercise-induced anaphylaxis: is wheat unique? Current allergy and asthma reports, 13 (6). pp. 639-44. ISSN 1534-6315.

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Official URL: http://link.springer.com/article/10.1007%2Fs11882-...

Abstract

This review draws comparisons between wheat-dependent exercise-induced anaphylaxis (WDEIA) and other food-dependent exercise-induced anaphylaxis (FDEIAs) and discusses the importance of co-factors in its pathophysiology. FDEIA remains an enigmatic condition since it was first described 30 years ago. The sporadic and unpredictable nature of its reactions has puzzled clinicians and scientists for decades, but recent studies on WDEIA have enlightened us about the pathophysiology of this condition. The identification of defined allergic epitopes such as Tri a 19, α-gliadin, β-gliadin and γ-gliadin in WDEIA enables it to become the perfect model for studying FDEIA, but WDEIA is by no means a unique condition. On a larger scale, FDEIA represents a crucial link between IgE-mediated and anaphylactoid reactions and provides supportive evidence for the concept of 'summation anaphylaxis' and the need to overcome the 'allergen threshold'. Future work should focus on identifying more of the FDEIA epitopes and understanding their distinct molecular properties. The development of a biomarker in order to identify patients susceptible to co-factor influences would be invaluable.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD300 Hypersensitivity. Allergy
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Suganthi Vijayaganesh
Date Deposited: 25 Nov 2014 15:38
Last Modified: 25 Nov 2014 15:38
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/665

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