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Worldwide, mortality risk is high soon after initiation of hemodialysis.

Robinson, Bruce M and Zhang, Jinyao and Morgenstern, Hal and Bradbury, Brian D and Ng, Leslie J and McCullough, Keith P and Gillespie, Brenda W and Hakim, Raymond and Rayner, Hugh C and Fort, Joan and Akizawa, Tadao and Tentori, Francesca and Pisoni, Ronald L (2014) Worldwide, mortality risk is high soon after initiation of hemodialysis. Kidney international, 85 (1). pp. 158-65. ISSN 1523-1755. Full Text available via 'Related URL' link

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Official URL: http://www.nature.com/ki/journal/v85/n1/full/ki201...

Abstract

Mortality rates for maintenance hemodialysis patients are much higher than the general population and are even greater soon after starting dialysis. Here we analyzed mortality patterns in 86,886 patients in 11 countries focusing on the early dialysis period using data from the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study of in-center hemodialysis. The primary outcome was all-cause mortality, using time-dependent Cox regression, stratified by study phase adjusted for age, sex, race, and diabetes. The main predictor was time since dialysis start as divided into early (up to 120 days), intermediate (121-365 days), and late (over 365 days) periods. Mortality rates (deaths/100 patient-years) were 26.7 (95% confidence intervals 25.6-27.9), 16.9 (16.2-17.6), and 13.7 (13.5-14.0) in the early, intermediate, and late periods, respectively. In each country, mortality was higher in the early compared to the intermediate period, with a range of adjusted mortality ratios from 3.10 (2.22-4.32) in Japan to 1.15 (0.87-1.53) in the United Kingdom. Adjusted mortality rates were similar for intermediate and late periods. The ratio of elevated mortality rates in the early to the intermediate period increased with age. Within each period, mortality was higher in the United States than in most other countries. Thus, internationally, the early hemodialysis period is a high-risk time for all countries studied, with substantial differences in mortality between countries. Efforts to improve outcomes should focus on the transition period and the first few months of dialysis.

Item Type: Article
Additional Information: Full Text available via 'Related URL' link
Subjects: WH Haemic and lymphatic systems. Haematology
Divisions: Planned IP Care > Oncology and Clinical Haematology
Related URLs:
Depositing User: Sophie Rollason
Date Deposited: 08 Jul 2014 09:58
Last Modified: 08 Jul 2014 09:58
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/587

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