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Dynamics of raltegravir resistance profile in an HIV type 2-infected patient.

Xu, Li and Anderson, Jane and Garrett, Nigel and Ferns, Bridget and Wildfire, Adrian and Cook, Pamela and Workman, Judith and Graham, Susan and Smit, Erasmus (2009) Dynamics of raltegravir resistance profile in an HIV type 2-infected patient. AIDS research and human retroviruses, 25 (8). pp. 843-7. ISSN 1931-8405.

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Official URL: http://online.liebertpub.com/doi/abs/10.1089/aid.2...

Abstract

The evolutionary dynamics of RAL resistance in the HIV-2 virus were examined through population and clonal sequence analysis of the IN from baseline, during treatment, and after stopping RAL therapy. The treatment failure of an RAL regimen in the HIV-2 patient studied was associated with the emergence of mutations via the N155H resistance pathway and subsequent switching to the Y143C mutational route. This study has also identified four novel secondary mutations, Q91R, S147G, A153G, and M183I, not previously reported in HIV-1 patients failing RAL therapy. Resistant variants involving the Y143C pathway were noted to have persisted beyond 4 weeks following the cessation of RAL therapy. All resistance-associated mutations were lost at 20 weeks after stopping RAL therapy. Our findings provide evidence supporting the supposition that substantial cross-resistance between strand transfer IN-Is is likely in HIV-2 as shown in HIV-1.

Item Type: Article
Subjects: WC Communicabable diseases
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Preeti Puligari
Date Deposited: 28 Aug 2014 14:53
Last Modified: 28 Aug 2014 14:53
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/581

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