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Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans.

Tan, Bee K and Chen, Jing and Hu, Jiamiao and Amar, Omar and Mattu, Harman S and Ramanjaneya, Manjunath and Patel, Vanlata and Lehnert, Hendrik and Randeva, Harpal S (2014) Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. Clinical endocrinology. ISSN 1365-2265.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/cen.124...

Abstract

OBJECTIVE

Adipolin/CTRP12 is a novel adipokine with anti-inflammatory and glucose-lowering properties in rodents. We sought to investigate the effects of metformin treatment (850 mg twice daily for 6 months) and a 2 h 75 g oral glucose tolerance test (OGTT) on serum adipolin concentrations in humans.

DESIGN

Cross-sectional study [PCOS (n = 83) and control (n = 39) subjects]. Serum adipolin was measured by ELISA. Metformin treatment (850 mg twice daily for 6 months) was offered to all women with PCOS, 34 women participated but 21 women completed 6 months of metformin therapy. Reasons for subjects not completing the study were nausea and gastrointestinal side effects (n = 4), pregnancies (n = 5), noncompliance (n = 2) and loss of contact (n = 2).

RESULTS

Metformin treatment (850 mg twice daily for 6 months) substantially increased serum adipolin concentrations (P < 0·05) in women with polycystic ovary syndrome (PCOS), a pro-inflammatory state associated with obesity, diabetes, dyslipidaemia and atherosclerosis. Furthermore, changes in waist-hip ratio, glucose, triglycerides, CRP and carotid intima media thickness showed significant negative associations with changes in adipolin levels (P < 0·05, P < 0·01); in multiple regression analyses, only changes in glucose were predictive of changes in adipolin levels (β = -0·570, P = 0·009). Serum adipolin decreased significantly in response to the OGTT in PCOS and control subjects at 90 min (P < 0·05) and 120 min (P < 0·01).

CONCLUSIONS

Adipolin and/or novel pharmacologic agents that increase adipolin's circulating concentrations might constitute a novel approach in the treatment of insulin resistant states.

Item Type: Article
Subjects: WK Endocrine system. Endocrinology
Divisions: Womens and Childrens > Gynaecology
Womens and Childrens > Obstetrics
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Depositing User: Mrs Yolande Brookes
Date Deposited: 19 Aug 2014 10:21
Last Modified: 19 Aug 2014 10:21
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/540

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