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Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV.

Taylor, Stephen and Davies, Sophia (2010) Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV. Current opinion in HIV and AIDS, 5 (4). pp. 335-43. ISSN 1746-6318.

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Official URL: http://journals.lww.com/co-hivandaids/Abstract/201...

Abstract

PURPOSE OF REVIEW

To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract.

RECENT FINDINGS

Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentrations achieved vary considerably depending on the class of drug studied, the sampling techniques used and the times samples are obtained.

SUMMARY

There appear to be several patterns of drug penetration into the male and female genital tract. In addition there appear to be different patterns of genital shedding under the influence of antiretroviral therapy. What effect these factors will have on the sexual transmission of HIV or the evolution and transmission of resistant HIV remains to be seen.

Item Type: Article
Subjects: WC Communicabable diseases
Divisions: Clinical Support > Infectious Diseases
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 04 Jul 2014 09:04
Last Modified: 04 Jul 2014 09:04
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/479

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