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The relationship between aortic aneurysm sac thrombus volume on coagulation, fibrinolysis and platelet activity.

Davies, Robert S M and Abdelhamid, Mohamed and Vohra, Rajiv K and Bradbury, Andrew W and Adam, Donald J (2012) The relationship between aortic aneurysm sac thrombus volume on coagulation, fibrinolysis and platelet activity. Thrombosis research, 130 (3). pp. 463-6. ISSN 1879-2472. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs

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Official URL: http://www.thrombosisresearch.com/issue/S0049-3848...

Abstract

AIM

Abdominal aortic aneurysm (AAA) is associated with chronic mural inflammation and a pro-thrombotic diathesis. It has been suggested that both may be related to biologically active intra-sac thrombus. The aim of this study was to examine the relationship between thrombin generation, fibrinolysis, platelet activity and AAA sac thrombus volume.

METHODS

30 patients (29 men) of median (IQR) age 75 (71-82) years with an infra-renal AAA >5.5 cm in antero-posterior diameter were prospectively studied. AAA, lumen and thrombus volumes were calculated using a CT workstation (Vitrea). Plasma thrombin-antithrombin (TAT), plasminogen activator inhibitor (PAI)-1, and soluble (s) P-selectin were measured as biomarkers of coagulation, fibrinolysis and platelet activity, respectively

RESULTS

Median (IQR) AAA total, lumen and thrombus volumes were 188 (147-247) cm(3), 80 (54.3-107) cm(3) and 97.6 (63-127) cm(3) respectively. TAT levels were significantly higher (median, QR, 7.15 [4.7-31.3] μg/L, p=<0.001) and sP-selectin levels significantly lower (median, IQR, 80.5 [68-128] ng/ml, p=<0.0001) than the normal range. PAI-1 levels (median, IQR, 20.9 [8.4-50.7] ng/ml) were normal. There was no correlation between AAA thrombus volume and PAI-1 (r=-0.25, p=0.47), sP-Selectin (r=0.26, p=0.43) or TAT plasma levels (r=-0.21, p=0.54).

CONCLUSION

The present study confirms that patients with AAA demonstrate haemostatic derangement, but the extent of the haemostatic derangement does not correlate with AAA sac thrombus volume.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Subjects: WG Cardiovascular system. Cardiology
Divisions: Planned IP Care > Vascular
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Depositing User: Mrs Yolande Brookes
Date Deposited: 18 Aug 2014 12:53
Last Modified: 18 Aug 2014 12:53
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/457

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