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Toponome imaging system: multiplex biomarkers in oncology.

Evans, Robert G and Naidu, Babu V and Rajpoot, Nasir M and Epstein, David and Khan, Michael (2012) Toponome imaging system: multiplex biomarkers in oncology. Trends in molecular medicine, 18 (12). pp. 723-31. ISSN 1471-499X. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their Athens login IDs

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Official URL: http://www.cell.com/trends/molecular-medicine/home

Abstract

Toponome imaging systems (TIS) can yield high-resolution subcellular colocalization images of multiple proteins within single cells and intact tissue sections, giving this technology significant potential for identifying multiplex biomarkers that simultaneously measure several aspects of a cell. The integral role of the microenvironment in malignant progression and the recently appreciated heterogeneity of cancer cells underscore the importance of characterizing complex molecular phenotypes and the large protein network structures of single cells within their preserved anatomical context. Here, we discuss the TIS technique and the potential for developing new sensitive and specific multiplex biomarkers for risk stratification and diagnosis, in addition to its utility for anticancer drug discovery by identifying 'hub' proteins that are essential regulators of protein networks.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their Athens login IDs
Subjects: QZ Pathology. Oncology
Divisions: Planned IP Care > Oncology and Clinical Haematology
Planned IP Care > Thoracic Surgery
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Depositing User: Mrs Yolande Brookes
Date Deposited: 04 Jul 2014 10:53
Last Modified: 04 Jul 2014 10:53
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/401

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