Taylor, Stephen and Jayasuriya, Ashini N and Berry, Amanda and Gilleran, Gerry and Dufty, Ngozi E and Else, Laura and Back, David J and Smit, Erasmus J (2010) Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men. AIDS (London, England), 24 (16). pp. 2583-7. ISSN 1473-5571. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IdsFull text not available from this repository.
Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
|Additional Information:||This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login Ids|
WC Communicabable diseases
|Divisions:||Clinical Support > Infectious Diseases|
|Depositing User:||Mr Philip O'Reilly|
|Date Deposited:||27 Jun 2014 14:44|
|Last Modified:||27 Jun 2014 14:44|
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