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Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Taylor, Stephen and Jayasuriya, Ashini N and Berry, Amanda and Gilleran, Gerry and Dufty, Ngozi E and Else, Laura and Back, David J and Smit, Erasmus J (2010) Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men. AIDS (London, England), 24 (16). pp. 2583-7. ISSN 1473-5571. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login Ids

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Official URL: http://ovidsp.uk.ovid.com/sp-3.12.0b/ovidweb.cgi?&...

Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login Ids
Subjects: QV Pharmacology
WC Communicabable diseases
Divisions: Clinical Support > Infectious Diseases
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 27 Jun 2014 14:44
Last Modified: 27 Jun 2014 14:44
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/393

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