Fibrates and estimated glomerular filtration rate: observations from an outpatient clinic setting and clinical implications.

Abbas, Ahmed and Saraf, Sanjay and Ramachandran, Shanath and Raju, Jessie and Ramachandran, Sudarshan (2012) Fibrates and estimated glomerular filtration rate: observations from an outpatient clinic setting and clinical implications. Postgraduate medical journal, 88 (1043). pp. 503-6. ISSN 1469-0756. You can access the full text of the article using your HEFT Athens ID via NHS Evidence www.evidence.nhs.uk

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Abstract

BACKGROUND

Previous studies have demonstrated that fibrates have an effect on creatinine concentrations. The pattern of change with fibrates in estimated glomerular filtration rate (eGFR), widely used in clinical practice, has not been previously described.

METHODS

Data was retrospectively collected from 132 consecutive case notes of patients started on fibrates in a lipid clinic between 2002 and 2008. Pre- and post-fibrate creatinine concentrations were measured and eGFR measurements were obtained.

RESULTS

Of the 79 patients with both pre and post-treatment eGFR values <90 ml/min/1.73 m(2), a significant mean eGFR reduction of 8.2 ml/min/1.73 m(2) was noted. Of these patients, 50% demonstrated a reduction in eGFR >8 ml/min/1.73 m(2), 25% demonstrated a reduction >16 ml/min/1.73 m(2), and 10% demonstrated a reduction >21 ml/min/1.73 m(2).

CONCLUSIONS

The authors demonstrate a significant effect of fibrates on eGFR in clinical practice. Awareness of the pattern of eGFR change is important for decisions regarding the continued use of fibrate therapy and/or commonly co-prescribed diabetic drugs and renal specialist referrals.

Item Type:	Article
Additional Information:	You can access the full text of the article using your HEFT Athens ID via NHS Evidence www.evidence.nhs.uk
Subjects:	QU Biochemistry
Divisions:	Clinical Support > Pathology
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/?term...
Depositing User:	Mrs Caroline Tranter
Date Deposited:	03 Jul 2014 15:24
Last Modified:	03 Jul 2014 15:25
URI:	http://www.repository.heartofengland.nhs.uk/id/eprint/385

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