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Regional changes in bone area and bone mineral content in boys with duchenne muscular dystrophy receiving corticosteroid therapy.

Crabtree, Nicola J and Roper, Helen and McMurchie, Heather and Shaw, Nicholas J (2010) Regional changes in bone area and bone mineral content in boys with duchenne muscular dystrophy receiving corticosteroid therapy. The Journal of pediatrics, 156 (3). pp. 450-5. ISSN 1097-6833. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs

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Official URL: http://www.jpeds.com/article/S0022-3476(09)00879-8...

Abstract

OBJECTIVE

To examine the functional and skeletal effects of 30 months of steroid treatment in boys with Duchenne muscular dystrophy.

STUDY DESIGN

Lumbar spine (L(2)L(4)) and subcranial dual energy X-ray absorptiometry scanning was performed on 25 boys (mean age 7.4 years) at baseline and after 30 months of steroid treatment.

RESULTS

At baseline, L(2)L(4) bone mineral content (BMC) was significantly low for projected bone area although appropriate for reduced lean body mass (LBM). Subcranial bone area for height and subcranial BMC for area and LBM were all significantly reduced. After 30 months of steroid therapy there was a significant increase in subcranial bone area for height but a significant reduction of subcranial BMC for area. At the lumbar spine there were no significant changes in bone area but small increases in L(2)L(4) BMC both for bone area and LBM.

CONCLUSION

At baseline reduced mechanical load from diminished muscle function results in narrow light bones more noticeable in the subcranial region than the lumbar spine. Increases observed in subcranial bone area at 30 months suggest a gradual adaptation to increased gravitational load whereas at the spine there were no apparent detrimental effects on bone after 30 months of steroid therapy.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Subjects: WE Musculoskeletal. Orthopaedics
WL Nervous system. Neurology
Divisions: Womens and Childrens > Paediatrics
Related URLs:
Depositing User: Sophie Rollason
Date Deposited: 11 Jun 2014 12:45
Last Modified: 11 Jun 2014 12:45
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/236

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