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Multiple myeloma with monoclonal free IgG3 heavy chains and free kappa light chains.

Richter, Alex G and Harding, Stephen and Huissoon, Aarnoud and Drayson, Mark and Pratt, Guy (2010) Multiple myeloma with monoclonal free IgG3 heavy chains and free kappa light chains. Acta Haematologica, 123 (3). pp. 158-61. ISSN 1421-9662.

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Official URL: http://www.karger.com/Article/FullText/292899

Abstract

We describe the case of a 34-year-old gentleman investigated for persistent neutropaenia following two episodes of pneumonia. Specialist investigations led to the diagnosis of multiple myeloma (MM) producing a truncated monoclonal gamma(3) heavy chain (HC) immunoglobulin molecule unattached to a light chain (LC) with atypical features for both MM and HC disease. Western blot showed gamma(3)HC was truncated with a large deletion (75 kDa). Flow cytometry of the bone marrow aspirate revealed an unusual staining pattern. This plasma cell dyscrasia was also unusual in that a subpopulation (30%) secreted large quantities of free LC (FLC) as well as truncated IgG HC. This is the first description, investigation and treatment of MM with a plasma cell population producing truncated gamma(3)HC and kappaFLC M-proteins and illustrates a number of unique immunological and clinical features.

Item Type: Article
Subjects: QW Microbiology. Immunology
Divisions: Clinical Support > Pathology
Emergency Services > Acute Medicine and AMU
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Depositing User: Preeti Puligari
Date Deposited: 24 Jun 2014 15:07
Last Modified: 24 Jun 2014 15:07
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/230

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