White Matter Microstructure in Youths With Conduct Disorder: Effects of Sex and Variation in Callous Traits.

Rogers, Jack C and Gonzalez-Madruga, Karen and Kohls, Gregor and Baker, Rosalind H and Clanton, Roberta L and Pauli, Ruth and Birch, Philippa and Chowdhury, Alimul I and Kirchner, Marietta and Andersson, Jesper L R and Smaragdi, Areti and Puzzo, Ignazio and Baumann, Sarah and Raschle, Nora M and Fehlbaum, Lynn V and Menks, Willeke M and Steppan, Martin and Stadler, Christina and Konrad, Kerstin and Freitag, Christine M and Fairchild, Graeme and De Brito, Stéphane A (2019) White Matter Microstructure in Youths With Conduct Disorder: Effects of Sex and Variation in Callous Traits. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 1527-5418. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://jaacap.org/article/S0890-8567(19)30251-5/f...

Abstract

OBJECTIVE

Studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations in a large sample of youths with CD, and examined the influence of sex and callous-unemotional (CU) traits.

METHOD

DTI-data were acquired from 124 youths with CD (59 female youth) and 174 typically-developing (TD) youths (103 female youth) aged 9-18 years. Tract-based spatial statistics tested for effects of diagnosis and sex-by-diagnosis interactions. Associations with CD symptoms, CU traits, a task measuring impulsivity, and the impact of comorbidity and age- and puberty-related effects were examined.

RESULTS

Youths with CD exhibited higher axial-diffusivity in the corpus callosum and lower radial-diffusivity and mean-diffusivity in the anterior thalamic radiation relative to TD youths. Female and male youth with CD exhibited opposite changes within the internal capsule, fornix, posterior thalamic radiation and uncinate fasciculus. Within the CD group, CD symptoms and callous traits exerted opposing influences on corpus callosum axial-diffusivity, with callous traits identified as the unique clinical feature predicting higher axial-diffusivity and lower radial-diffusivity within the corpus callosum and anterior thalamic radiation, respectively. In an exploratory analysis, corpus callosum axial-diffusivity partially mediated the association between callous traits and impulsive responses to emotional faces. Results were not influenced by symptoms of comorbid disorders and no age- or puberty-related interactions were observed.

CONCLUSION

WM alterations within the corpus callosum represent a reliable neuroimaging marker of CD. Sex and callous traits are important factors to consider when examining WM in CD.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WL Nervous system. Neurology
WM Psychiatry. Mental health
Divisions: Clinical Support
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Depositing User: Miss Emily Johnson
Date Deposited: 10 May 2019 14:39
Last Modified: 10 May 2019 14:39
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/2095

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