False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

Maddison, Paul and Sadalage, Girija and Ambrose, Philip Alexander and Jacob, Saiju and Vincent, Angela (2019) False-positive acetylcholine receptor antibody results in patients without myasthenia gravis. Journal of neuroimmunology, 332. pp. 69-72. ISSN 1872-8421. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://linkinghub.elsevier.com/retrieve/pii/S0165...

Abstract

Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two patients had transiently raised AChR antibodies associated with Guillain-Barré syndrome. Antibodies to clustered AChRs, in a live cell-based assay, were negative in all five patients, suggesting that results from the RIAs were false-positives. It is possible that the AChR antibodies detected by RIA in these cases were non-pathogenic, and directed to intracellular epitopes of the AChR.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WL Nervous system. Neurology
Divisions: Emergency Services > Neurology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 16 Apr 2019 10:18
Last Modified: 16 Apr 2019 10:18
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/2036

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