Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management.

Mollan, Susan P and Ali, Fizzah and Hassan-Smith, Ghaniah and Botfield, Hannah and Friedman, Deborah I and Sinclair, Alexandra J (2016) Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management. Journal of neurology, neurosurgery, and psychiatry, 87 (9). pp. 982-92. ISSN 1468-330X.

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Official URL: https://jnnp.bmj.com/content/87/9/982.long

Abstract

Idiopathic intracranial hypertension (IIH) is a rare but important disease associated with significant morbidity. There is an expected rise in prevalence in line with the escalating global burden of obesity. Modern revisions in the terminology and diagnostic criteria for IIH help guide clinicians in investigations and researchers in standardising recruitment criteria for clinical trials. The pathophysiology of IIH is incompletely characterised; suggested underpinning mechanisms include the role of cerebrospinal fluid regulation as well as metabolic and endocrinological perspectives. Recent treatment trials are providing insights into the management but debate still surrounds key areas in treatment. This review will provide an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.

Item Type: Article
Subjects: WL Nervous system. Neurology
Divisions: Emergency Services > Neurology
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Depositing User: Jennifer Manders
Date Deposited: 03 Apr 2019 13:19
Last Modified: 03 Apr 2019 13:19
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1993

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