The use of error and uncertainty methods in the medical laboratory.

Oosterhuis, Wytze P and Bayat, Hassan and Armbruster, David and Coskun, Abdurrahman and Freeman, Kathleen P and Kallner, Anders and Koch, David and Mackenzie, Finlay and Migliarino, Gabriel and Orth, Matthias and Sandberg, Sverre and Sylte, Marit S and Westgard, Sten and Theodorsson, Elvar (2018) The use of error and uncertainty methods in the medical laboratory. Clinical chemistry and laboratory medicine, 56 (2). pp. 209-219. ISSN 1437-4331.

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Abstract

Error methods - compared with uncertainty methods - offer simpler, more intuitive and practical procedures for calculating measurement uncertainty and conducting quality assurance in laboratory medicine. However, uncertainty methods are preferred in other fields of science as reflected by the guide to the expression of uncertainty in measurement. When laboratory results are used for supporting medical diagnoses, the total uncertainty consists only partially of analytical variation. Biological variation, pre- and postanalytical variation all need to be included. Furthermore, all components of the measuring procedure need to be taken into account. Performance specifications for diagnostic tests should include the diagnostic uncertainty of the entire testing process. Uncertainty methods may be particularly useful for this purpose but have yet to show their strength in laboratory medicine. The purpose of this paper is to elucidate the pros and cons of error and uncertainty methods as groundwork for future consensus on their use in practical performance specifications. Error and uncertainty methods are complementary when evaluating measurement data.

Item Type: Article
Subjects: WB Practice of medicine
Divisions: Clinical Support
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Depositing User: Mr Philip O'Reilly
Date Deposited: 19 Mar 2019 15:34
Last Modified: 19 Mar 2019 15:34
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1948

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