Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time-dependent analysis.

Thayakaran, R and Perrins, M and Gokhale, K M and Kumaran, S and Narendran, Parth and Price, M J and Nirantharakumar, Krishnarajah and Toulis, K A (2019) Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time-dependent analysis. Diabetic medicine : a journal of the British Diabetic Association. ISSN 1464-5491. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/dm...

Abstract

AIMS

To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes.

METHODS

People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA included as a time-dependent variable was fitted to these data.

RESULTS

Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA .

CONCLUSIONS

In people with newly diagnosed Type 1 diabetes, higher HbA is associated with an increased risk for fractures. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Diabetes
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Depositing User: Miss Emily Johnson
Date Deposited: 15 Mar 2019 14:27
Last Modified: 15 Mar 2019 14:27
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1923

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