Reviewing the Pathophysiology Behind the Advances in the Management of Giant Cell Arteritis.

Al-Mousawi, Alia Z and Gurney, Sam P and Lorenzi, Alice R and Pohl, Ute and Dayan, Margaret and Mollan, Susan P (2019) Reviewing the Pathophysiology Behind the Advances in the Management of Giant Cell Arteritis. Ophthalmology and therapy. ISSN 2193-8245. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Improving understanding of the underlying pathophysiology of giant cell arteritis (GCA) is transforming clinical management by identifying novel avenues for targeted therapies. One key area of concern for both clinicians and patients with GCA is glucocorticoid (GC) morbidity. The first randomised controlled trials of targeted treatment to reduce cumulative GC use in GCA have been published, with tocilizumab, an interleukin (IL)-6 receptor inhibitor, now the first ever licensed treatment for GCA. Further potential therapies are emerging owing to our enhanced understanding of the pathophysiology of the disease. Other improvements in the care of our patients are rapid access pathways and imaging techniques, such as ultrasound, which are becoming part of modern rheumatology practice in the UK, Europe and beyond. These have been highlighted in the literature to reduce delay in diagnosis and improve long-term outcomes for those investigated for GCA.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Miss Emily Johnson
Date Deposited: 11 Mar 2019 11:43
Last Modified: 11 Mar 2019 11:43
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1905

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