Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A H NMR-Based Metabolomics Analysis.

Hao, Yu and Zheng, Hong and Wang, Ruo-Han and Li, Hui and Yang, Li-Li and Bhandari, Suwas and Liu, Yong-Jian and Han, Jun and Smith, Fang Gao and Gao, Hong-Chang and Jin, Sheng-Wei (2019) Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A H NMR-Based Metabolomics Analysis. Mediators of inflammation, 2019. p. 2309175. ISSN 1466-1861. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and puncture- (CLP-) induced septic mice. We found that MaR1 significantly increased the overall survival rate and attenuated lung and liver injuries in septic mice. In addition, MaR1 markedly reduced the levels of proinflammatory cytokines (TNF- and IL-6) and alleviated mitochondrial damage. Based on a H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs. However, these metabolic disorders, mainly involving energy and amino acid metabolism, can be recovered by MaR1 treatment. Therefore, our results suggest that the protective effects of MaR1 on sepsis could be related to the recovery of metabolic dysfunction and the alleviation of inflammation and mitochondrial damage.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin
WD Diseases and disorders of systemic, metabolic or environmental origin > WD250 Metabolic diseases
Divisions: Clinical Support > Anaesthetics
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Depositing User: Miss Emily Johnson
Date Deposited: 04 Mar 2019 12:00
Last Modified: 04 Mar 2019 12:00
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1882

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