Repeated adrenaline doses and survival from an out-of-hospital cardiac arrest.

Fothergill, Rachael T and Emmerson, Amber C and Iyer, Rajeshwari and Lazarus, Johanna and Whitbread, Mark and Nolan, Jerry P and Deakin, Charles D and Perkins, Gavin D (2019) Repeated adrenaline doses and survival from an out-of-hospital cardiac arrest. Resuscitation. ISSN 1873-1570. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

Full text not available from this repository.
Official URL: https://www.resuscitationjournal.com/article/S0300...

Abstract

BACKGROUND

Adrenaline is the primary drug of choice for resuscitation from out-of-hospital cardiac arrest (OHCA). Although adrenaline may increase the chance of achieving return of spontaneous circulation (ROSC), there is limited evidence that repeated doses of adrenaline improves overall survival, and increasing evidence of a detrimental effect on neurological function in survivors. This paper reports the relationship between repeated doses of adrenaline and survival in a cohort of patients attended by the London Ambulance Service in the United Kingdom.

METHODS

A retrospective review of OHCA treated by the London Ambulance Service over a one year period. Patients aged ≥18 years who received one or more doses of adrenaline (1 mg bolus) during resuscitation were included in the analyses. Outcomes described are survival to hospital discharge and survival to one year post-arrest.

RESULTS

Over the one year study period, 3151 patients received adrenaline during OHCA. A significant inverse relationship was found between increasing cumulative doses of adrenaline and survival both to hospital discharge and one year post-arrest. No patients survived after receiving more than ten adrenaline doses.

CONCLUSION

Our study indicates that repeated doses of adrenaline are associated with decreasing odds of survival. There were no survivors amongst patients requiring more than 10 doses of adrenaline.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WB Practice of medicine > WB400 Intensive care
WG Cardiovascular system. Cardiology
Divisions: Clinical Support > Critical Care
Related URLs:
Depositing User: Mrs Semanti Chakraborty
Date Deposited: 28 Feb 2019 09:21
Last Modified: 28 Feb 2019 09:21
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1871

Actions (login required)

View Item View Item