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Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

Jayasuriya, A N and Itzhaki, R F and Wozniak, M A and Patel, R and Smit, E J and Noone, R and Gilleran, G and Taylor, Stephen and White, D J (2008) Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV. Sexually transmitted infections, 84 (7). pp. 516-7. ISSN 1472-3263. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs

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Official URL: http://sti.bmj.com/content/84/7/516.long

Abstract

Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Subjects: WC Communicabable diseases
Divisions: Ambulatory Care > Outpatients
Related URLs:
Depositing User: Sophie Rollason
Date Deposited: 10 Jun 2014 13:21
Last Modified: 10 Jun 2014 13:21
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/177

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