Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

Bamford, A and Turkova, A and Lyall, H and Foster, C and Klein, N and Bastiaans, D and Burger, D and Bernadi, S and Butler, K and Chiappini, E and Clayden, P and Della Negra, M and Giacomet, V and Giaquinto, C and Gibb, D and Galli, L and Hainaut, M and Koros, M and Marques, L and Nastouli, E and Niehues, T and Noguera-Julian, A and Rojo, P and Rudin, C and Scherpbier, H J and Tudor-Williams, G and Welch, S B (2018) Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life. HIV medicine, 19 (1). e1-e42. ISSN 1468-1293. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/10.1111/hiv.12...

Abstract

The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short-term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic HIV infection on immune system development and health in general. Additionally, there is a greater need for increased awareness and minimization of long-term drug toxicity. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy (ART) at all ages (higher CD4 thresholds for consideration of ART initiation and additional clinical indications), revised guidance on first- and second-line ART recommendations, including more recently available drug classes, expanded guidance on management of coinfections (including tuberculosis, hepatitis B and hepatitis C) and additional emphasis on the needs of adolescents as they approach transition to adult services. There is a new section on the current ART 'pipeline' of drug development, a comprehensive summary table of currently recommended ART with dosing recommendations. Differences between PENTA and current US and World Health Organization guidelines are highlighted and explained.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WS Paediatrics. Child health
Divisions: Womens and Childrens > Paediatrics
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Depositing User: Mrs Semanti Chakraborty
Date Deposited: 16 Jul 2018 15:54
Last Modified: 16 Jul 2018 15:54
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1699

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