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An unusual case of leptomeningeal carcinomatosis in a patient with primary adenocarcinoma of the lung.

Tinsley, Nadina and Yemula, Nikitha and Ramalingam, Satheesh and Madathil, Shyam (2018) An unusual case of leptomeningeal carcinomatosis in a patient with primary adenocarcinoma of the lung. BMJ case reports, 2018. ISSN 1757-790X. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Official URL: http://casereports.bmj.com/cgi/pmidlookup?view=lon...

Abstract

A 72-year-old man was brought to the emergency department with acute onset confusion and haemoptysis. Chest X-ray showed a possible lung mass, while CT head showed a fluid-filled, space-occupying lesion (SOL) in the right frontal lobe of the brain. MRI head indicated that this SOL had spilt its contents into the subarachnoid and intraventricular spaces. Due to a fluctuating Glasgow Coma Scale (GCS), the patient underwent emergency debulking. Macroscopically, a frail-walled cystic tumour filled with straw-coloured fluid was noted; histology confirmed metastasis from a primary lung adenocarcinoma. Whole brain radiotherapy was given, with a view to commence systemic therapy. The patient, however, deteriorated and unfortunately passed away a few weeks after completing radiotherapy. This patient presented with leptomeningeal metastasis as the first presentation of a lung adenocarcinoma, and had a highly unusual mechanism by which leptomeningeal spread had occurred, with metastatic brain tumour spilling its contents into the meningeal spaces.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: QZ Pathology. Oncology
WF Respiratory system. Respiratory medicine
WS Paediatrics. Child health
Divisions: Planned IP Care > Oncology and Clinical Haematology
Planned IP Care > Respiratory Medicine
Womens and Childrens > Paediatrics
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 06 Jul 2018 14:12
Last Modified: 06 Jul 2018 14:12
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1693

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