Unmasking leading to a health care worker Mycobacterium tuberculosis transmission.

Holden, Kerry L and Bradley, Craig W and Curran, Evonne T and Pollard, Christopher and Smith, Grace and Holden, Elisabeth and Glynn, Patricia and Garvey, Mark (2018) Unmasking leading to a health care worker Mycobacterium tuberculosis transmission. The Journal of hospital infection. ISSN 1532-2939. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Official URL: https://linkinghub.elsevier.com/retrieve/pii/S0195...

Abstract

BACKGROUND

Mycobacterium tuberculosis is a major health burden worldwide. The disease can present as an individual case, community outbreak or more rarely a nosocomial outbreak. Even in countries with a low prevalence such as the UK, tuberculosis (TB) presents a risk to healthcare workers (HCWs).

AIM

To report an outbreak which manifested 12 months after a patient with pulmonary tuberculosis was admitted to Queen Elizabeth Hospital Birmingham (QEHB).

METHODS

We present the epidemiological and outbreak investigations; the role of whole genome sequencing (WGS) in identifying the outbreak and control measures to prevent further outbreaks.

FINDINGS

Subsequent to a case of open tuberculosis in a patient transmission was confirmed in one healthcare worker (HCW) who had active TB; HCW cases of latent TB infection (LTBI) were also identified amongst 7 HCW contacts of the index case. Of note, all the LBTI cases had other risk factors for TB. Routine use of Whole Genome Sequencing (WGS) identified the outbreak link between the index case to the HCW with active TB disease, and also informed our investigations.

CONCLUSIONS

Exposure most likely occurred during an aerosol generating procedure (AGP) which was done in accordance with national guidance at that time without using respiratory protection. Enhanced control measures were implemented following the outbreak.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Mr Philip O'Reilly
Date Deposited: 04 Jun 2018 13:29
Last Modified: 04 Jun 2018 13:29
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1661

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