HEFT Repository

Alternatives to Biologics in Management of Knee Osteoarthritis: A Systematic Review.

Hassan, Fadi and Murrell, William D and Refalo, Andrew and Maffulli, Nicola (2018) Alternatives to Biologics in Management of Knee Osteoarthritis: A Systematic Review. Sports medicine and arthroscopy review, 26 (2). pp. 79-85. ISSN 1538-1951. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

Full text not available from this repository.
Official URL: https://journals.lww.com/sportsmedarthro/Pages/def...

Abstract

BACKGROUND

Knee osteoarthritis (KOA) is a common condition encountered by physicians. KOA is addressed by a wide array of modalities including a number of nonbiological treatments.

METHODS

PubMed, ISI Web of Science, and SPORTDiscus were searched for level 1 to 4 studies published from inception to August 2017.

RESULTS

A total of 18 studies were evaluated and results demonstrated moderate supporting evidence for prolotherapy and limited evidence for botulinum toxin type A, sodium bicarbonate and calcium gluconate, and low-molecular weight fraction of 5% human serum albumin. Evidence for local anesthetic agents was conflicting.

CONCLUSION

There is moderate supportive evidence for the effectiveness of prolotherapy in improving pain and function in both, short-term and long-term. Limited supporting evidence found for botulinum toxin type A, sodium bicarbonate and calcium gluconate, and low-molecular weight fraction of 5% human serum albumin in improving pain and function. There is conflicting evidence for the use of local anesthetic agents in patients with KOA.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD811 Rheumatology
WE Musculoskeletal. Orthopaedics
Divisions: Planned IP Care > Trauma and Orthopaedics
Related URLs:
Depositing User: Mrs Caroline Tranter
Date Deposited: 04 May 2018 13:29
Last Modified: 04 May 2018 13:29
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1640

Actions (login required)

View Item View Item