The Association between Obstructive Sleep Apnoea and Metabolic Abnormalities in Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis.

Kahal, Hassan and Kyrou, Ioannis and Uthman, Olalekan and Brown, Anna and Johnson, Samantha and Wall, Peter and Metcalfe, Andrew and Tahrani, Abd A and Randeva, Harpal S (2018) The Association between Obstructive Sleep Apnoea and Metabolic Abnormalities in Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Sleep. ISSN 1550-9109. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Abstract

Study Objectives

In this systematic review and meta-analysis, we aimed to examine the relationship between obstructive sleep apnoea (OSA) and metabolic abnormalities in women with polycystic ovary syndrome (PCOS).

Methods

Electronic databases (Medline, Embase, Cinahl, PsycInfo, Scopus, Web of Science, Opengrey, CENTRAL), conference abstracts, and reference lists of relevant articles were searched. No restriction was applied for language or publication status.

Results

Six studies involving 252 participants were included. Women with PCOS and OSA had significantly higher body mass index (mean difference [MD]: 6.01 kg/m 2, 95% Confidence Intervals [CI]: 4.69-7.33), waist circumference (MD: 10.93 cm, 95% CI: 8.03-13.83), insulin resistance, systolic and diastolic blood pressure, as well as worse lipids' profile and impaired glucose regulation compared to women with PCOS without OSA. Most studies did not adjust for weight in their between groups analysis. Total and free testosterone levels were not significantly different between the two groups. The majority of studies were found to be at high risk of selection bias; did not account for important confounders; were conducted in one country (USA); and used different methodologies to assess testosterone levels (preventing a meta-analysis for this specific outcome).

Conclusions

OSA is associated with obesity and worse metabolic profiles in women with PCOS. However, whether the effects of OSA are independent of obesity remain unclear. As OSA is a treatable condition, research focused on the independent effects of OSA on key clinical outcomes in women with PCOS, including fertility, psychological health, type 2 diabetes and cardiovascular risk is lacking and needed.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WK Endocrine system. Endocrinology
WL Nervous system. Neurology
Divisions: Ambulatory Care > Diabetes
Related URLs:
Depositing User: Mrs Caroline Tranter
Date Deposited: 04 May 2018 13:23
Last Modified: 04 May 2018 13:23
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1638

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