Amiodarone-Induced Thyroid Dysfunction: A Clinical Update.

Elnaggar, Mohamed Nabil and Jbeili, Kahtan and Nik-Hussin, Nik and Kozhippally, Mohandas and Pappachan, Joseph M (2018) Amiodarone-Induced Thyroid Dysfunction: A Clinical Update. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. ISSN 1439-3646. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Official URL: https://www.thieme-connect.com/DOI/DOI?10.1055/a-0...

Abstract

Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Amiodarone-induced hypothyroidism (AIH) is diagnosed and managed in the same way as a usual case of hypothyroidism. However, differential diagnosis and clinical management of amiodarone-induced thyrotoxicosis (AIT) subtypes can be challenging. With the aid of a case snippet, we update the current evidence for the diagnostic work up and management of patients with amiodarone-induced thyroid dysfunction in this article.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WK Endocrine system. Endocrinology
Divisions: Emergency Services > Acute Medicine and AMU
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Depositing User: Mrs Caroline Tranter
Date Deposited: 10 Apr 2018 13:01
Last Modified: 10 Apr 2018 13:01
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1626

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