A retrospective cohort study of patients treated with anti-tuberculous therapy for presumed ocular tuberculosis.

Damato, Erika Marie and Dawson, Sarah and Liu, Xiaoxuan and Mukherjee, Chandoshi and Horsburgh, John and Denniston, Alastair K and Moran, Edward and Dedicoat, Martin and Murray, Philip Ian (2017) A retrospective cohort study of patients treated with anti-tuberculous therapy for presumed ocular tuberculosis. Journal of ophthalmic inflammation and infection, 7 (1). p. 23. ISSN 1869-5760. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Abstract

BACKGROUND

Uveitis involving the posterior segment is a significant and potentially blinding condition. The diagnosis and treatment of patients with uveitis associated with tuberculosis remains controversial, and commonly, patients are systemically well. Use of the interferon-gamma release assays has added to the controversy, as the significance of a positive test may be uncertain. We aim to report the outcomes of anti-tuberculous treatment in a cohort of patients treated in Birmingham, for presumed "ocular tuberculosis", based on clinical findings, systemic assessment and specific testing for tuberculosis.

RESULTS

We found that in our cohort of 41 patients treated between 2010 and 2014, the majority achieved disease-free remission, even in cases where anti-tuberculous treatment was delayed.

CONCLUSIONS

Despite controversy, this study strongly supports the use of anti-tuberculous therapy in such patients and highlights the need for formal prospective trials and treatment protocols.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Clinical Support > Infectious Diseases
Planned IP Care > Respiratory Medicine
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Depositing User: Mrs Semanti Chakraborty
Date Deposited: 17 Apr 2018 15:45
Last Modified: 17 Apr 2018 15:45
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1555

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