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The concordance between component tests and clinical history in British adults with suspected pollen-food syndrome to peanut and hazelnut.

Beck, Sarah C and Huissoon, Aarnoud P and Collins, Donna and Richter, Alex G and Krishna, Mamidipudi T (2017) The concordance between component tests and clinical history in British adults with suspected pollen-food syndrome to peanut and hazelnut. Journal of clinical pathology. ISSN 1472-4146. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

Full text not available from this repository.
Official URL: http://jcp.bmj.com/content/early/2017/08/05/jclinp...

Abstract

BACKGROUND

Mild oropharyngeal symptoms to peanut/hazelnut occur in ~30% of patients with pollen-food syndrome (PFS). Component tests are considered a useful adjunct to the diagnosis and may help differentiate PFS from those at a risk of anaphylaxis due to storage protein/lipid transfer protein (LTP) sensitisation.

AIMS

To assess concordance between component tests and clinical history in suspected PFS to peanut/hazelnut in a specialist clinic.

METHODS

Adult patients were classified into PFS (group 1, n=69) and PFS with mild systemic symptoms (group 2, n=45) based on clinical history. Specific IgE (sIgE) of ≥0.35 kUA/L was considered positive as per manufacturers’ recommendation. Kappa (κ) inter-rater agreement was calculated for concordance between clinical classification and test profiles.

RESULTS

Group 1 hazelnut: 85% monosensitised to Cor a1, 12% to storage protein/s or LTP and 3% negative to all components. Group 1 peanut: 41% monosensitised to Ara h8, 44% to storage protein/s or ±LTP and 15% negative to all components. Group 2 hazelnut: 67% monosensitised to Cor a1, 16% sensitised to storage protein/s and 17% negative to all components. Group 2 peanut: 19% monosensitised to Ara h8, 62% sensitised to storage protein/s and/or LTP and 19% negative to all components.SIgE to Ara h8 and Cor a1 were greater in group 1 versus group 2: (median (IQR) kUA/L; hazelnut: 12.1 (7.8-25.2) vs 2.4 (0.36-6.3), p<0.001; peanut: 2.4 (0.10-21.1) vs 0.3 (0-3), p<0.01)).

CONCLUSION

Concordance between component tests and clinical history for adults with PFS was good for hazelnut (κ=0.63) but poor for peanut (κ=âˆ'0.12). Food challenges are warranted in discordant cases for an accurate diagnosis.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: QW Microbiology. Immunology
Divisions: Emergency Services > Acute Medicine and AMU
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 27 Nov 2017 15:16
Last Modified: 27 Nov 2017 15:16
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1534

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