HEFT Repository

Anovulation with or without PCO, hyperandrogenaemia and hyperinsulinaemia as promoters of endometrial and breast cancer.

Papaioannou, Spyros and Tzafettas, John (2010) Anovulation with or without PCO, hyperandrogenaemia and hyperinsulinaemia as promoters of endometrial and breast cancer. Best practice & research. Clinical obstetrics & gynaecology, 24 (1). pp. 19-27. ISSN 1532-1932. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs

Full text not available from this repository. (Request a copy)
Official URL: http://www.bestpracticeobgyn.com/article/S1521-693...

Abstract

The relationship of infertility, endocrinology and cancer has become clearer in recent years. Polycystic ovaries (PCO) increase the risk of endometrial cancer. Prolonged amenorrhoea, therefore, should be prevented in such cases with the use of cyclical progestogens, in order for regular withdrawal bleeds to be induced and the endometrium protected from long-term unopposed oestrogen stimulation. There is no secure evidence base on which a relationship between PCO and breast cancer can be based. No specific breast screening for women with PCO is, therefore, recommended. Hyperandrogenaemia and hyperinsulinaemia are conditions whose significance in terms of increasing both endometrial and breast cancer risks is increasingly recognised. The exact mechanism with which they influence carcinogenesis is still far from clear. Whether they act in isolation or as expressions of the common background of the metabolic syndrome - in interaction with other components of this syndrome - is still the subject of research.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Subjects: WP Gynaecology. Women’s health
Divisions: Womens and Childrens > Gynaecology
Related URLs:
Depositing User: Sophie Rollason
Date Deposited: 10 Jun 2014 13:28
Last Modified: 10 Jun 2014 13:28
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/150

Actions (login required)

View Item View Item