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pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure.

McNamee, J J and Gillies, M A and Barrett, N A and Agus, A M and Beale, R and Bentley, A and Bodenham, A and Brett, S J and Brodie, D and Finney, S J and Gordon, A J and Griffiths, M and Harrison, D and Jackson, C and McDowell, C and McNally, C and Perkins, G D and Tunnicliffe, W and Vuylsteke, A and Walsh, T S and Wise, M P and Young, D and McAuley, D F (2017) pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure. Journal of the Intensive Care Society, 18 (2). pp. 159-169. ISSN 1751-1437.

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Official URL: http://journals.sagepub.com/doi/abs/10.1177/175114...

Abstract

One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2R) can facilitate reducing tidal volumes. pRotective vEntilation with veno-venouS lung assisT (REST) is a randomised, allocation concealed, controlled, open, multicentre pragmatic trial to determine the clinical and cost-effectiveness of lower tidal volume mechanical ventilation facilitated by vv-ECCO2R in patients with acute hypoxaemic respiratory failure. Patients requiring intubation and mechanical ventilation for acute hypoxaemic respiratory failure will be randomly allocated to receive either vv-ECCO2R and lower tidal volume mechanical ventilation or standard care with stratification by recruitment centre. There is a need for a large randomised controlled trial to establish whether vv-ECCO2R in acute hypoxaemic respiratory failure can allow the use of a more protective lung ventilation strategy and is associated with improved patient outcomes.

Item Type: Article
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Clinical Support > Critical Care
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 23 Nov 2017 15:22
Last Modified: 23 Nov 2017 15:22
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1496

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