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Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype.

Bevan, Edward R and Jones, Annie M and Hawkey, Peter M (2017) Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype. The Journal of antimicrobial chemotherapy. ISSN 1460-2091.

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Official URL: https://academic.oup.com/jac/article-abstract/doi/...

Abstract

Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27. Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.

Item Type: Article
Subjects: W Public health. Health statistics. Occupational health. Health education
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 22 Jun 2017 10:01
Last Modified: 22 Jun 2017 10:01
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1415

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