HEFT Repository

Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study.

Altaf, Quratul A and Dodson, Paul and Ali, Asad and Raymond, Neil T and Wharton, Helen and Fellows, Hannah and Hampshire-Bancroft, Rachel and Shah, Mirriam and Shepherd, Emma and Miah, Jamili and Barnett, Anthony H and Tahrani, Abd A (2017) Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study. American journal of respiratory and critical care medicine. ISSN 1535-4970. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

Full text not available from this repository.
Official URL: http://www.atsjournals.org/doi/abs/10.1164/rccm.20...

Abstract

AIMS

To assess the relationship between obstructive sleep apnoea (OSA) and diabetic retinopathy (DR) in patients with type 2 diabetes (T2D) and to assess whether OSA is associated with its progression).

METHODS

A longitudinal study from diabetes clinics in two UK hospitals was conducted. Patients known to have any respiratory disorder (including OSA) were excluded. DR was assessed using 2x45degrees retinal images per eye. OSA was assessed using a home-based, multi-channel cardiorespiratory device.

RESULTS

230 patients were included. Sight threatening DR (STDR) and OSA prevalence was 36.1% and 63.9% respectively. STDR prevalence was higher in patients with OSA (OSA+) vs. those without (OSA-) (42.9% vs. 24.1% (p0.004). After adjustment for confounders, OSA remained independently associated with STDR (OR 2.3, 95%CI 1.1-4.9, p=0.04). After a median (IQR) follow-up of 43.0 (37.0-51.0) months, OSA+ patients were more likely to develop pre-/proliferative DR compared to OSA- patients (18.4% vs. 6.1%, p=0.02). After adjustment for confounders, OSA remained an independent predictor of progression to pre-/proliferative DR (OR 5.2, 95%CI 1.2-23.0, p=0.03). Patients who received continuous positive airway pressure (CPAP) treatment were significantly less likely to develop pre-/proliferative DR.

CONCLUSIONS

OSA is associated with STDR in patients with T2D. OSA is an independent predictor for the progression to pre-/proliferative DR. CPAP treatment was associated with reduction in pre-/proliferative DR. Interventional studies are needed to assess the impact of OSA treatment on STDR.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
WK Endocrine system. Endocrinology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Diabetes
Ambulatory Care > Ophthalmology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 22 Jun 2017 09:44
Last Modified: 22 Jun 2017 09:44
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1413

Actions (login required)

View Item View Item