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Biomarkers of oxidative stress and antioxidants in severe asthma: A Prospective Case-Control Study.

Bishopp, Abigail and Sathyamurthy, Ramamurthy and Manney, Sarah and Webbster, Craig and Krishna, Mamidipudi Thirumala and Mansur, Adel H (2017) Biomarkers of oxidative stress and antioxidants in severe asthma: A Prospective Case-Control Study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 118 (4). pp. 445-451. ISSN 1534-4436. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

Full text not available from this repository.
Official URL: http://www.annallergy.org/article/S1081-1206(17)30...

Abstract

BACKGROUND

Bronchial airway inflammation is the hallmark of asthma, which may be driven by an imbalance between oxidative stress and antioxidant defenses. Antioxidants deficiency may play a role, but this has remained unconfirmed.

OBJECTIVE

To evaluate the oxidative stress burden and antioxidants defenses in patients with increasing asthma severity.

METHODS

This prospective case-control study compared fractional exhaled nitric oxide (FeNO), exhaled breath condensate nitrite/nitrate (EBC-NOx), spirometry, and serum vitamins and trace elements among patients with and without asthma.

RESULTS

Sixty participants were recruited (30 with severe asthma number; 23 women [76.7%]; mean age, 41.4 years; mean forced expiratory volume in 1 second [FEV1], 2.2 L [72.2% predicted]; mean inhaled corticosteroid dosage, 2,540 μg/d; 18/30 [60%] receiving maintenance oral corticosteroids; 15 with mild asthma; all corticosteroids naïve; 9 women [60%]; mean age, 34.6 years; mean FEV1, 3.48 L [100.5% predicted]; 15 healthy controls; 12 women [80%]; mean age, 37.6 years; and mean FEV1, 3.53 L [111.7% predicted]). The mean FeNO levels increased significantly with increasing asthma severity (P = .01), but the EBC-NOx levels did not change significantly (P = .90). Paradoxically, vitamin A and vitamin E increased with increased disease severity, with vitamin E levels increasing significantly (P = .07 and P < .001, respectively). There was no significant difference between groups in the levels of copper (P = .37), zinc (P = .97), or selenium (P = .90).

CONCLUSION

FeNO but not EBC-NOx is increased significantly with asthma severity with no evidence of vitamins or trace elements deficiency in severe asthma. Impaired oxidative stress defenses in severe asthma may be driven by factors other than vitamins or trace elements deficiency.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: QW Microbiology. Immunology
WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 01 Jun 2017 14:02
Last Modified: 01 Jun 2017 14:02
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1394

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