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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney, Liam G and Djukanovic, Ratko and Woodcock, Ashley and Walker, Samantha and Matthews, John G and Pavord, Ian D and Bradding, Peter and Niven, Robert and Brightling, Chris E and Chaudhuri, Rekha and Arron, Joseph R and Choy, David F and Cowan, Douglas and Mansur, Adel H and Menzies-Gow, Andrew and Adcock, Ian and Chung, Kian F and Corrigan, Chris and Coyle, Peter and Harrison, Timothy and Johnston, Sebastian and Howarth, Peter and Lordan, James and Sabroe, Ian and Bigler, Jeannette and Smith, Dirk and Catley, Matthew and May, Richard and Pierre, Lisa and Stevenson, Chris and Crater, Glenn and Keane, Frank and Costello, Richard W and Hudson, Val and Supple, David and Hardman, Tim (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71 (2). pp. 187-9. ISSN 1468-3296. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

Full text not available from this repository.
Official URL: http://thorax.bmj.com/content/71/2/187.long

Abstract

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 03 Apr 2017 15:23
Last Modified: 03 Apr 2017 15:23
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1367

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