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Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial.

Forrester, Doug L and Knox, Alan J and Smyth, Alan R and Barr, Helen L and Simms, Rebecca and Pacey, Sarah J and Pavord, Ian D and Honeybourne, David and Dewar, Jane and Clayton, Andy and Fogarty, Andrew W (2016) Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial. Pediatric pulmonology, 51 (3). pp. 253-7. ISSN 1099-0496. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

Full text not available from this repository.
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ppul.23...

Abstract

RATIONALE

Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.

METHODS

The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.

RESULTS

Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.

CONCLUSIONS

There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Mr Philip O'Reilly
Date Deposited: 03 Apr 2017 11:33
Last Modified: 03 Apr 2017 11:33
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1351

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