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The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

Hassan, Fadi and Trebinjac, Suad and Murrell, William D and Maffulli, Nicola (2017) The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review. British medical bulletin. pp. 1-18. ISSN 1471-8391. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

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Official URL: https://academic.oup.com/bmb/article-abstract/doi/...

Abstract

Introduction

Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise.

Sources of data

Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016.

Areas of agreement

Ten studies were evaluated and results show significant improvement in scores for pain, function and range of motion, both in the short term and long term. Patient satisfaction was also high in these patients (82%).

Areas of controversy

Meta-analysis was not possible due to heterogeneity of outcome measures and populations.

Growing points

Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

Areas for developing research

Future research should focus on larger sample size, standardization of treatment protocol and basic science evidence.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: WE Musculoskeletal. Orthopaedics
Divisions: Ambulatory Care > Rheumatology
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 24 Mar 2017 15:09
Last Modified: 24 Mar 2017 15:09
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1284

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