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T-cell abnormalities in common variable immunodeficiency: the hidden defect.

Wong, Gabriel K and Huissoon, Aarnoud P (2016) T-cell abnormalities in common variable immunodeficiency: the hidden defect. Journal of clinical pathology, 69 (8). pp. 672-6. ISSN 1472-4146.

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Official URL: http://jcp.bmj.com/content/69/8/672.long

Abstract

This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg Group 1a patients and those suffering from inflammatory complications. The reductions in T-cell receptor excision circles, naïve T cells, invariant NKT cells and regulatory T cells suggest a diminished thymic output, while CD8 T cells are driven towards exhaustion either via an antigen-dependent or an antigen-independent manner. The theoretical risk of anti-T-cell therapies is discussed, highlighting the need for an international effort in generating longitudinal data in addition to better-defined underlying molecular characterisation.

Item Type: Article
Subjects: QZ Pathology. Oncology
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 10 Feb 2017 09:38
Last Modified: 10 Feb 2017 09:38
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1179

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