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Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions.

Morgentaler, Abraham and Zitzmann, Michael and Traish, Abdulmaged M and Fox, Anthony W and Jones, T Hugh and Maggi, Mario and Arver, Stefan and Aversa, Antonio and Chan, Juliana C N and Dobs, Adrian S and Hackett, Geoffrey I and Hellstrom, Wayne J and Lim, Peter and Lunenfeld, Bruno and Mskhalaya, George and Schulman, Claude C and Torres, Luiz O (2016) Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions. Mayo Clinic proceedings, 91 (7). pp. 881-96. ISSN 1942-5546. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login

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Official URL: http://www.mayoclinicproceedings.org/article/S0025...

Abstract

To address widespread concerns regarding the medical condition of testosterone (T) deficiency (TD) (male hypogonadism) and its treatment with T therapy, an international expert consensus conference was convened in Prague, Czech Republic, on October 1, 2015. Experts included a broad range of medical specialties including urology, endocrinology, diabetology, internal medicine, and basic science research. A representative from the European Medicines Agency participated in a nonvoting capacity. Nine resolutions were debated, with unanimous approval: (1) TD is a well-established, clinically significant medical condition that negatively affects male sexuality, reproduction, general health, and quality of life; (2) symptoms and signs of TD occur as a result of low levels of T and may benefit from treatment regardless of whether there is an identified underlying etiology; (3) TD is a global public health concern; (4) T therapy for men with TD is effective, rational, and evidence based; (5) there is no T concentration threshold that reliably distinguishes those who will respond to treatment from those who will not; (6) there is no scientific basis for any age-specific recommendations against the use of T therapy in men; (7) the evidence does not support increased risks of cardiovascular events with T therapy; (8) the evidence does not support increased risk of prostate cancer with T therapy; and (9) the evidence supports a major research initiative to explore possible benefits of T therapy for cardiometabolic disease, including diabetes. These resolutions may be considered points of agreement by a broad range of experts based on the best available scientific evidence.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login
Subjects: WJ Urogenital system. Urology
Divisions: Planned IP Care > General Surgery
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Depositing User: Miss Adele Creak
Date Deposited: 30 Jan 2017 13:48
Last Modified: 30 Jan 2017 13:48
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1130

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